TTD Target ID: TTDR01361

Target Information
Name	mRNA of HER2
Type of target	Research target
Disease	Not Available
UniProt ID	P04626
Target Validation	Click to Find Target Validation Information.
Inhibitor	(1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine		[1]
	17-allylamino-17-desmethoxy-geldanamycin		[2]
	3,4-di- (4-methoxyphenyl)-1H-pyrrole-2,5-dione		[3]
	3,4-diphenyl-1H-pyrrole-2,5-dione		[3]
	3- (4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione		[3]
	3- (indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione		[3]
	4- (3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole		[4]
	4- (4-bromophenyl)-5-cyano-2H-1,2,3-triazole		[4]
	4- (4-chlorophenyl)-5-cyano-2H-1,2,3-triazole		[4]
	4- (4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole		[4]
	4- (Bis		[5]
	AG-213		[6]
	BMS-536924		[7]
	CL-387785		[8]
	Lapatinib ditosylate		[9]
	N- (4-m-Tolylamino-quinazolin-6-yl)-acrylamide		[10]
	NERATINIB		[11]
	PD-168393		[10]
	geldanamycin-estradiol hybrid		[12]
	geldanamycin-estradiol hybrid		[12]
Antisense	ISIS 12882		[13]
	ISIS 12883		[13]
	ISIS 12884		[13]
	ISIS 9002		[13]
	ISIS 9003		[13]
	ISIS 9005		[13]
Cross References	3D Structure Related Literature On-Line Medical Dictionary
Ref 1	Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5.Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. To Reference
Ref 2	Bioorg Med Chem. 2009 Mar 15;17(6):2225-35. Epub 2008 Nov 6.Discovery and development of heat shock protein 90 inhibitors. To Reference
Ref 3	J Med Chem. 2006 Feb 23;49(4):1271-81.Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. To Reference
Ref 4	Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. Epub 2006 Dec 15.Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. To Reference
Ref 5	Bioorg Med Chem. 2010 Jan 15;18(2):880-6. Epub 2009 Nov 22.Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents. To Reference
Ref 6	Eur J Med Chem. 2008 Jul;43(7):1478-88. Epub 2007 Sep 29.Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors. To Reference
Ref 7	J Med Chem. 2005 Sep 8;48(18):5639-43.Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. To Reference
Ref 8	J Med Chem. 2006 Feb 23;49(4):1475-85.Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. To Reference
Ref 9	Bioorg Med Chem Lett. 2009 Nov 15;19(22):6437-40. Epub 2009 Sep 17.Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors. To Reference
Ref 10	J Med Chem. 1999 May 20;42(10):1803-15.Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor. To Reference
Ref 11	Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. Epub 2007 Dec 6.Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. To Reference
Ref 12	Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8.Synthesis and evaluation of geldanamycin-estradiol hybrids. To Reference
Ref 13	US Patent 5968748 To Reference

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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