Therapeutic Targets Database
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TTD Target ID: TTDR01420

Target Information
NamemRNA of Aurora B    
Type of targetResearch target    
DiseaseNot Available    
UniProt IDQ96GD4
Target ValidationClick to Find Target Validation Information.    
Inhibitor4- (1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine[1]
4- (4'-Benzamidoanilino)-6,7-dimethoxyquinazoline[2]
6-bromoindirubin-3-oxime[3]
7-bromoindirubin-3-oxime[3]
7-chloroindirubin-3-oxime[3]
7-fluoroindirubin-3-acetoxime[3]
7-fluoroindirubin-3-oxime[3]
7-iodoindirubin-3-oxime[3]
AZD-1152-HQPA,   Barasertib[4]
CGP-57380[5]
GSK-1070916[6]
HESPERADIN[7]
PHA-680632[8]
SU 6656[5]
indirubin-3-acetoxime[3]
indirubin-3-methoxime[3]
indirubin-3-oxime[3]
AntisenseISIS 173813[9]
ISIS 173831[9]
ISIS 173840[9]
ISIS 173848[9]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. Epub 2010 Mar 1.Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. To Reference
Ref 2Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. To Reference
Ref 3J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. To Reference
Ref 4J Med Chem. 2009 May 14;52(9):2629-51.Discovery and development of aurora kinase inhibitors as anticancer agents. To Reference
Ref 5Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. To Reference
Ref 6J Med Chem. 2010 May 27;53(10):3973-4001.Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. To Reference
Ref 7J Med Chem. 2006 Feb 9;49(3):955-70.Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. To Reference
Ref 8J Med Chem. 2005 Apr 21;48(8):3080-4.Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. To Reference
Ref 9US Patent 7375212 To Reference



 

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