Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00035

Target Information
NameBeta adrenergic receptor    
Type of targetSuccessful target    
DiseaseNoninsulin-dependent diabetes mellitus    [1]
Obesity    [1]
Schizophrenia    [2]
Drug(s)ArbutamineApprovedCoronary artery disease [3]
BretyliumApprovedAV (atrioventricular) heart block[5][6]
DipivefrinApprovedOpen-angle glaucoma[11]
EpinephrineApprovedAnaphylaxis and sepsis[12]
IsoproterenolApprovedBradycardia or heart block[15][16]
LevobunololApprovedOpen-angle glaucoma[17]
MetipranololApprovedOpen-angle glaucoma and ocular hypertension[18]
NadololApprovedHigh blood pressure and angina[19]
NorepinephrineApprovedSeptic shock and neurogenic shock[20]
PindololApprovedHypertension and angina[23]
RitodrineApprovedPremature labour[25][26]
TimololApprovedHigh blood pressure[27][28][29]
BioChemical ClassTransmembrane protein    
PathwayCalcium signaling pathway
Neuroactive ligand-receptor interaction
Related US Patent6,297,382
Target ValidationClick to Find Target Validation Information.    
AgonistBRL 35135[1]
Antagonist (-)-propranolol[24]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Clinical pharmacology of beta 3-adrenoceptors. Br J Clin Pharmacol. 1996 Sep;42(3):291-300. To Reference
Ref 2Potential noradrenergic targets for cognitive enhancement in schizophrenia. CNS Spectr. 2004 May;9(5):350-5. To Reference
Ref 3Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Cardiovasc Drugs Ther. 1996 Mar;10(1):39-47. To Reference
Ref 4Withdrawal syndromes and the cessation of antihypertensive therapy. Arch Intern Med. 1981 Aug;141(9):1125-7. To Reference
Ref 5Components of functional sympathetic control of heart rate in neonatal rats. Am J Physiol. 1985 May;248(5 Pt 2):R601-10. To Reference
Ref 6Dissociation of autonomic controls of heart rate in weaning-aged borderline hypertensive rats by perinatal NaCl. J Auton Nerv Syst. 1990 Mar;29(3):219-26. To Reference
Ref 7Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. Jpn J Pharmacol. 2000 Nov;84(3):287-92. To Reference
Ref 8Effects of prolonged treatment with beta-adrenoceptor antagonist, carteolol on systemic and regional hemodynamics in stroke-prone spontaneously hypertensive rats. J Pharmacobiodyn. 1991 Feb;14(2):94-100. To Reference
Ref 9Regulation of a presynaptic adenylate cyclse from bovine cerebellum by beta-adrenergic receptors. Biochim Biophys Acta. 1980 Jun 20;599(1):167-74. To Reference
Ref 10Pharmacology and mechanism of action of cryptenamine. J Pharm Sci. 1966 Sep;55(9):888-93. To Reference
Ref 11Contractile response of the isolated trabecular meshwork and ciliary muscle to cholinergic and adrenergic agents. Ger J Ophthalmol. 1996 May;5(3):146-53. To Reference
Ref 12Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77. Epub 2009 May 21. To Reference
Ref 13Adrenergic receptor agonists. Conformation of erythro and threo forms of compounds related to ephedrine and isoetharine. Acta Pharm Suec. 1977;14(1):30-6. To Reference
Ref 14Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. Int J Obes (Lond). 2005 Jul;29(7):746-54. To Reference
Ref 15Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12. To Reference
Ref 16Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007 Feb 16;100(3):391-8. Epub 2007 Jan 18. To Reference
Ref 17Binding of beta-adrenoceptor antagonists to rat and rabbit lung: special reference to levobunolol. Arzneimittelforschung. 1984;34(5):579-84. To Reference
Ref 18Invited review: Neuroprotective properties of certain beta-adrenoceptor antagonists used for the treatment of glaucoma. J Ocul Pharmacol Ther. 2005 Jun;21(3):175-81. To Reference
Ref 19Bleeding caused by portal hypertension. Gastroenterol Clin North Am. 2005 Dec;34(4):623-42. To Reference
Ref 20Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31. To Reference
Ref 21beta-Adrenergic receptor blockers--a group of chiral drugs: different effects of each enantiomer. Ceska Slov Farm. 2002 May;51(3):121-8. To Reference
Ref 22Decrease in penbutolol central response as a cause of changes in its serum protein binding. J Pharm Pharmacol. 1990 Mar;42(3):164-6. To Reference
Ref 23Are we misunderstanding beta-blockers. Int J Cardiol. 2007 Aug 9;120(1):10-27. Epub 2007 Apr 12. To Reference
Ref 24Beta-blockers in the treatment of hypertension: are there clinically relevant differences? Postgrad Med. 2009 May;121(3):90-8. To Reference
Ref 25Acute tocolysis for uterine activity reduction in term labor: a review. Obstet Gynecol Surv. 2008 Jun;63(6):383-8; quiz 405. To Reference
Ref 26Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence. J Med Chem. 2001 Apr 26;44(9):1436-45. To Reference
Ref 27Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95. To Reference
Ref 28Blockade of beta-adrenergic receptors prevents amphetamine-induced behavioural sensitization in rats: a putative role of the bed nucleus of the stria terminalis. Int J Neuropsychopharmacol. 2005 Dec;8(4):569-81. Epub 2005 Apr 19. To Reference
Ref 29A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects. Br J Clin Pharmacol. 1997 Mar;43(3):301-8. To Reference
Ref 30Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. To Reference


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