TTD Target ID: TTDS00040

Target Information
Name	Prostaglandin G/H synthase 1
Type of target	Successful target
Synonyms	COX-1
	Cyclooxygenase -1
	Cyclooxygenase-1
	PGH synthase 1
	PGHS-1
	PHS 1
	Prostaglandin H2 synthase 1
	Prostaglandin-endoperoxide synthase 1
Disease	Cardiovascular disease, unspecified    [1]
	Chronic inflammatory diseases    [2]
Drug(s)	Balsalazide		Approved	Inflammatory bowel disease	[3]
	Bromfenac		Approved	Postoperative inflammation	[4]
	Gamma-Homolinolenic acid		Approved	Dietary shortage	[5][6][7]
	Mesalazine		Approved	Ulcerative colitis	[8]
	Salicyclic acid		Approved	Acne vulgaris	[9]
	Salsalate		Approved	Rheumatoid arthritis and osteoarthritis	[10][11]
	Suprofen		Approved	Miosis during ocular surgery	[12]
BioChemical Class	Oxidoreductases acting on paired donors
EC Number	EC 1.14.99.1
Pathway	Arachidonic acid metabolism
	Metabolic pathways
UniProt ID	P23219
Function	May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Sequence	MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
Target Validation	Click to Find Target Validation Information.
QSAR Model	Click to Find Target QSAR Model.
Inhibitor	(-)-3-O-acetylspectaline		[13]
	(11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid		[14]
	(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid		[14]
	(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid		[14]
	(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid		[15]
	(R)-2-		[16]
	(S)-FLURBIPROFEN		[16]
	(Z)-2'-des-methyl sulindac sulfide		[17]
	1,2-dihydro-3- (2,3,4-trimethoxyphenyl)naphthalene		[18]
	1- (4-		[19]
	1- (4-		[19]
	1- (4-aminosulfonylphenyl)-2-		[20]
	1- (4-aminosulfonylphenyl)-2-		[20]
	2'-epi-guianin		[21]
	2,4'-Dimethoxy-5,3'-di- (2-propenyl)-biphenyl		[22]
	2- (1,1'-Biphenyl-4-Yl)Propanoic Acid		[15]
	2- (2,3,4-trimethoxyphenyl)-1H-indene		[18]
	2- (2-		[23]
	2- (2-Methylpropanoyl)-1,3,5-benzenetriol		[24]
	2- (2-methoxyphenyl)-1H-indene		[18]
	2- (3'-Allyl-biphenyl-4-yl)-propionic acid		[25]
	2- (3'-Ethyl-biphenyl-4-yl)-propionic acid		[25]
	2- (3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid		[25]
	2- (3'-Vinyl-biphenyl-4-yl)-propionic acid		[25]
	2- (3-Phenyl-propyl)-1,2-dihydro-indazol-3-one		[26]
	2- (N-		[27]
	2- (N-		[27]
	2- (p-Methylsulfonylbenzoyl)furan		[28]
	2-Benzyl-1,2-dihydro-indazol-3-one		[26]
	2-Bromoacetyl Group		[29]
	2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one		[26]
	2-Methyl-1,2-dihydro-indazol-3-one		[26]
	2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one		[26]
	2-Phenethyl-1,2-dihydro-indazol-3-one		[26]
	2-Phenyl-1,2-dihydro-indazol-3-one		[26]
	2-[4- (1H-Indol-5-yl)-phenyl]-propionic acid		[25]
	3 beta-O-acetyloleanolic acid		[30]
	3- (4-Methanesulfonyl-phenyl)-1-phenyl-propynone		[31]
	4'-Methoxy-5,3'-dipropyl-biphenyl-2ol		[22]
	4,5-Bis (4-chlorophenyl)-1,2-selenazole		[32]
	4,5-Bis (4-chlorophenyl)isothiazole		[33]
	4,5-Bis (4-methoxyphenyl)-1,2-selenazole		[32]
	4,5-Bis (4-methoxyphenyl)-3H-1,2-dithiol-3-one		[33]
	4,5-Bis (4-methoxyphenyl)-3H-1,2-dithiole-3-thione		[33]
	4,5-Bis (4-methoxyphenyl)isothiazole		[33]
	4- (4-Chlorophenyl)-5-		[33]
	4- (4-Chlorophenyl)-5-p-tolyl-1,2-selenazole		[32]
	4- (4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one		[33]
	4- (4-Chlorophenyl)-5-p-tolylisothiazole		[33]
	4- (5-		[33]
	4-amino-N- (2-chlorophenyl)benzenesulfonamide		[34]
	4-amino-N- (4-chlorophenyl)benzenesulfonamide		[34]
	4-amino-N-p-tolylbenzenesulfonamide		[34]
	5,3'-Dipropyl-biphenyl-2,4'-diol		[22]
	5- (2-1H-indenyl)-1,3-benzodioxole		[18]
	5- (2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline		[35]
	5- (4-Chlorophenyl)-4-		[33]
	5- (4-Chlorophenyl)-4-p-tolyl-1,2-selenazole		[32]
	5- (4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one		[33]
	5- (4-Chlorophenyl)-4-p-tolylisothiazole		[33]
	5- (4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole		[32]
	5- (4-Methoxyphenyl)-4-p-tolylisothiazole		[33]
	5-Ethyl-3,4-diphenyl-isoxazole		[36]
	5-Methyl-3,4-diphenyl-isoxazole		[36]
5-Phenyl-pentanoic acid benzyl-hydroxy-amide		[37]
Acetic Acid Salicyloyl-Amino-Ester		[15]
Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester		[38]
Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester		[38]
Acetic acid 2-heptylselanyl-phenyl ester		[38]
Acetic acid 2-heptylsulfanyl-phenyl ester		[38]
Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester		[38]
Acetic acid 2-hexylsulfanyl-phenyl ester		[38]
Acetic acid 2-pentylsulfanyl-phenyl ester		[38]
Alpha-D-Mannose		[29]
Arachidonic Acid		[29]
B-Octylglucoside		[29]
BW-755C		[39]
Balsalazide		[3]
Beta-D-Glucose		[29]
Beta-D-Mannose		[29]
Bromfenac		[4]
CATECHIN		[40]
CATECHIN		[40]
CIMICOXIB		[41]
CURCUMIN		[42]
DEMETHOXYCURCUMIN		[42]
DOCOSAHEXAENOIC ACID		[43]
EPICATECHIN		[40]
EPICATECHIN		[40]
FENBUFEN		[44]
Flufenamic Acid		[45]
Flurbiprofen Methyl Ester		[29]
Gamma-Homolinolenic acid		[5][6][7]
HONOKIOL		[22]
Heme		[15]
Hyperforin		[46]
IMRECOXIB		[47]
INDOPROFEN		[16]
IODOINDOMETHACIN		[48]
IODOSUPROFEN		[48]
L-745337		[49]
METHYLHONOKIOL		[22]
Mesalazine		[8]
N- (1H-indazol-5-yl)acetamide		[50]
N- (3-		[51]
N- (3-phenoxy-4-pyridinyl)ethanesulfonamide		[52]
N- (3-phenoxy-4-pyridinyl)propanesulfonamide		[52]
N- (3-phenoxypyridin-4-yl)methanesulfonamide		[51]
N- (3-phenylamino-4-pyridinyl)methanesulfonamide		[51]
O-Acetylserine		[29]
Oxametacin		[53]
P- (2'-Iodo-5'-Thenoyl)Hydrotropic Acid		[15]
PHENIDONE		[26]
Phenacetin		[54]
Prifelone		[55]
Primary alcohol metabolite of celecoxib		[56]
Protoporphyrin Ix Containing Co		[29]
R-KETOPROFEN		[16]
RESORCINOL		[40]
Resveratrol		[57]
Resveratrol		[1]
Resveratrol Potassium3-Sulfate		[58]
Resveratrol Potassium4,-Sulfate		[58]
SC-560		[59]
SC-58451		[60]
Salicyclic acid		[9]
Salsalate		[10][11]
Suprofen		[12]
TEBUFELONE		[61]
TENIDAP		[62]
alpha-Methyl-4-biphenyl-acetic acid		[48]
eicosapentaenoic acid		[43]
Cross References	3D Structure Related Literature On-Line Medical Dictionary
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Professor in Department of Pharmacy
National University of Singapore, Singapore

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