Target
Information |
Name | Prostaglandin G/H synthase 1 |
Type of target | Successful target |
Synonyms | COX-1 |
Cyclooxygenase -1 |
Cyclooxygenase-1 |
PGH synthase 1 |
PGHS-1 |
PHS 1 |
Prostaglandin H2 synthase 1 |
Prostaglandin-endoperoxide synthase 1 |
Disease | Cardiovascular disease, unspecified [1] |
Chronic inflammatory diseases [2] |
Drug(s) | Balsalazide |  | Approved | Inflammatory bowel disease | [3] |
Bromfenac |  | Approved | Postoperative inflammation | [4] |
Gamma-Homolinolenic acid |  | Approved | Dietary shortage | [5][6][7] |
Mesalazine |  | Approved | Ulcerative colitis | [8] |
Salicyclic acid |  | Approved | Acne vulgaris | [9] |
Salsalate |  | Approved | Rheumatoid arthritis and osteoarthritis | [10][11] |
Suprofen |  | Approved | Miosis during ocular surgery | [12] |
BioChemical Class | Oxidoreductases acting on paired donors |
EC Number | EC 1.14.99.1 |
Pathway | Arachidonic acid metabolism |
Metabolic pathways |
UniProt ID | P23219 |
Function | May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. |
Sequence | MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
Target Validation | Click to Find Target Validation Information. |
QSAR Model | Click to Find Target QSAR Model. |
Inhibitor | (-)-3-O-acetylspectaline |  | [13] |
(11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid |  | [14] |
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid |  | [14] |
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid |  | [14] |
(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid |  | [15] |
(R)-2- |  | [16] |
(S)-FLURBIPROFEN |  | [16] |
(Z)-2'-des-methyl sulindac sulfide |  | [17] |
1,2-dihydro-3- (2,3,4-trimethoxyphenyl)naphthalene |  | [18] |
1- (4- |  | [19] |
1- (4- |  | [19] |
1- (4-aminosulfonylphenyl)-2- |  | [20] |
1- (4-aminosulfonylphenyl)-2- |  | [20] |
2'-epi-guianin |  | [21] |
2,4'-Dimethoxy-5,3'-di- (2-propenyl)-biphenyl |  | [22] |
2- (1,1'-Biphenyl-4-Yl)Propanoic Acid |  | [15] |
2- (2,3,4-trimethoxyphenyl)-1H-indene |  | [18] |
2- (2- |  | [23] |
2- (2-Methylpropanoyl)-1,3,5-benzenetriol |  | [24] |
2- (2-methoxyphenyl)-1H-indene |  | [18] |
2- (3'-Allyl-biphenyl-4-yl)-propionic acid |  | [25] |
2- (3'-Ethyl-biphenyl-4-yl)-propionic acid |  | [25] |
2- (3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid |  | [25] |
2- (3'-Vinyl-biphenyl-4-yl)-propionic acid |  | [25] |
2- (3-Phenyl-propyl)-1,2-dihydro-indazol-3-one |  | [26] |
2- (N- |  | [27] |
2- (N- |  | [27] |
2- (p-Methylsulfonylbenzoyl)furan |  | [28] |
2-Benzyl-1,2-dihydro-indazol-3-one |  | [26] |
2-Bromoacetyl Group |  | [29] |
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one |  | [26] |
2-Methyl-1,2-dihydro-indazol-3-one |  | [26] |
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one |  | [26] |
2-Phenethyl-1,2-dihydro-indazol-3-one |  | [26] |
2-Phenyl-1,2-dihydro-indazol-3-one |  | [26] |
2-[4- (1H-Indol-5-yl)-phenyl]-propionic acid |  | [25] |
3 beta-O-acetyloleanolic acid |  | [30] |
3- (4-Methanesulfonyl-phenyl)-1-phenyl-propynone |  | [31] |
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol |  | [22] |
4,5-Bis (4-chlorophenyl)-1,2-selenazole |  | [32] |
4,5-Bis (4-chlorophenyl)isothiazole |  | [33] |
4,5-Bis (4-methoxyphenyl)-1,2-selenazole |  | [32] |
4,5-Bis (4-methoxyphenyl)-3H-1,2-dithiol-3-one |  | [33] |
4,5-Bis (4-methoxyphenyl)-3H-1,2-dithiole-3-thione |  | [33] |
4,5-Bis (4-methoxyphenyl)isothiazole |  | [33] |
4- (4-Chlorophenyl)-5- |  | [33] |
4- (4-Chlorophenyl)-5-p-tolyl-1,2-selenazole |  | [32] |
4- (4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one |  | [33] |
4- (4-Chlorophenyl)-5-p-tolylisothiazole |  | [33] |
4- (5- |  | [33] |
4-amino-N- (2-chlorophenyl)benzenesulfonamide |  | [34] |
4-amino-N- (4-chlorophenyl)benzenesulfonamide |  | [34] |
4-amino-N-p-tolylbenzenesulfonamide |  | [34] |
5,3'-Dipropyl-biphenyl-2,4'-diol |  | [22] |
5- (2-1H-indenyl)-1,3-benzodioxole |  | [18] |
5- (2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline |  | [35] |
5- (4-Chlorophenyl)-4- |  | [33] |
5- (4-Chlorophenyl)-4-p-tolyl-1,2-selenazole |  | [32] |
5- (4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one |  | [33] |
5- (4-Chlorophenyl)-4-p-tolylisothiazole |  | [33] |
5- (4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole |  | [32] |
5- (4-Methoxyphenyl)-4-p-tolylisothiazole |  | [33] |
5-Ethyl-3,4-diphenyl-isoxazole |  | [36] |
5-Methyl-3,4-diphenyl-isoxazole |  | [36] |
5-Phenyl-pentanoic acid benzyl-hydroxy-amide |  | [37] |
Acetic Acid Salicyloyl-Amino-Ester |  | [15] |
Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester |  | [38] |
Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester |  | [38] |
Acetic acid 2-heptylselanyl-phenyl ester |  | [38] |
Acetic acid 2-heptylsulfanyl-phenyl ester |  | [38] |
Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester |  | [38] |
Acetic acid 2-hexylsulfanyl-phenyl ester |  | [38] |
Acetic acid 2-pentylsulfanyl-phenyl ester |  | [38] |
Alpha-D-Mannose |  | [29] |
Arachidonic Acid |  | [29] |
B-Octylglucoside |  | [29] |
BW-755C |  | [39] |
Balsalazide |  | [3] |
Beta-D-Glucose |  | [29] |
Beta-D-Mannose |  | [29] |
Bromfenac |  | [4] |
CATECHIN |  | [40] |
CATECHIN |  | [40] |
CIMICOXIB |  | [41] |
CURCUMIN |  | [42] |
DEMETHOXYCURCUMIN |  | [42] |
DOCOSAHEXAENOIC ACID |  | [43] |
EPICATECHIN |  | [40] |
EPICATECHIN |  | [40] |
FENBUFEN |  | [44] |
Flufenamic Acid |  | [45] |
Flurbiprofen Methyl Ester |  | [29] |
Gamma-Homolinolenic acid |  | [5][6][7] |
HONOKIOL |  | [22] |
Heme |  | [15] |
Hyperforin |  | [46] |
IMRECOXIB |  | [47] |
INDOPROFEN |  | [16] |
IODOINDOMETHACIN |  | [48] |
IODOSUPROFEN |  | [48] |
L-745337 |  | [49] |
METHYLHONOKIOL |  | [22] |
Mesalazine |  | [8] |
N- (1H-indazol-5-yl)acetamide |  | [50] |
N- (3- |  | [51] |
N- (3-phenoxy-4-pyridinyl)ethanesulfonamide |  | [52] |
N- (3-phenoxy-4-pyridinyl)propanesulfonamide |  | [52] |
N- (3-phenoxypyridin-4-yl)methanesulfonamide |  | [51] |
N- (3-phenylamino-4-pyridinyl)methanesulfonamide |  | [51] |
O-Acetylserine |  | [29] |
Oxametacin |  | [53] |
P- (2'-Iodo-5'-Thenoyl)Hydrotropic Acid |  | [15] |
PHENIDONE |  | [26] |
Phenacetin |  | [54] |
Prifelone |  | [55] |
Primary alcohol metabolite of celecoxib |  | [56] |
Protoporphyrin Ix Containing Co |  | [29] |
R-KETOPROFEN |  | [16] |
RESORCINOL |  | [40] |
Resveratrol |  | [57] |
Resveratrol |  | [1] |
Resveratrol Potassium3-Sulfate |  | [58] |
Resveratrol Potassium4,-Sulfate |  | [58] |
SC-560 |  | [59] |
SC-58451 |  | [60] |
Salicyclic acid |  | [9] |
Salsalate |  | [10][11] |
Suprofen |  | [12] |
TEBUFELONE |  | [61] |
TENIDAP |  | [62] |
alpha-Methyl-4-biphenyl-acetic acid |  | [48] |
eicosapentaenoic acid |  | [43] |
Cross References |
3D Structure
Related Literature
On-Line
Medical Dictionary |
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