Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00163

Target Information
NameCalcium channel    
Type of targetSuccessful target    
DiseaseAnalgesics    [1]
Cerebral ischemia    [2]
Epilepsy    [3]
Head injury, unspecified    [4]
Hypertension    [5]
Pain, unspecified    [1]
Stroke    [6]
Unstable angina    [7]
Drug(s)FelodipineApprovedHypertension[8]
NicardipineApprovedHigh blood pressure and angina[9]
NimodipineApprovedCerebral vasospasm[10]
NisoldipineApprovedHypertension[11]
MEM-1003Phase IIa completedBipolar disorder[12]
BioChemical ClassVoltage-gated channel    
PathwayCalcium signaling pathway
MAPK signaling pathway
Taste transduction
Type II diabetes mellitus
Related US Patent6,323,243
6,334,997
6,344,461
6,469,038
6,492,375
6,495,715
6,573,280
6,617,322
6,638,930
Target ValidationClick to Find Target Validation Information.    
QSAR ModelClick to Find Target QSAR Model.    
BlockerFelodipine[8]
MEM-1003[12]
Nicardipine[9]
Nimodipine[10]
Nisoldipine[11]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Small molecules targeting sodium and calcium channels for neuropathic pain. Curr Opin Drug Discov Devel. 2009 Jul;12(4):543-61. To Reference
Ref 2Hemichannels in cerebral ischemia. Curr Mol Med. 2009 Mar;9(2):186-94. To Reference
Ref 3An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus. J Neurosci. 2009 Apr 8;29(14):4430-41. To Reference
Ref 4Magnesium for acute traumatic brain injury. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005400. To Reference
Ref 5Fixed-dose combinations of renin-angiotensin blocking agents with calcium channel blockers or hydrochlorothiazide in the treatment of hypertension. Expert Opin Pharmacother. 2009 Aug;10(11):1755-67. To Reference
Ref 6High blood pressure in acute ischaemic stroke--broadening therapeutic horizons. Cerebrovasc Dis. 2009;27 Suppl 1:156-61. Epub 2009 Apr 3. To Reference
Ref 7Acute coronary syndrome (unstable angina and non-ST elevation MI). Clin Evid (Online). 2009 Jan 13;2009. pii: 0209. To Reference
Ref 8Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. Epub 2008 Oct 30. To Reference
Ref 9Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention. Clin Cardiol. 2009 Jun;32(6):315-20. To Reference
Ref 10Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze. Pharmacol Rep. 2009 Mar-Apr;61(2):236-44. To Reference
Ref 11RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol. 2009;648:105-12. To Reference
Ref 12Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34. To Reference



 

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