Therapeutic Targets Database
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TTD Target ID: TTDS00210

Target Information
NamePenicillin binding protein    
Type of targetSuccessful target    
DiseaseBacterial infections    [1][2][3]
Drug(s)AmoxicillinApprovedBacterial infections[1]
AmpicillinApprovedBacterial infections[2]
AzlocillinApprovedBacterial infections[4]
BacampicillinApprovedBacterial infections[5]
CarbenicillinApprovedBacterial infections[6]
CefacetrileApprovedBacterial infections[7]
CefaclorApprovedBacterial infections[8]
CefadroxilApprovedBacterial infections[9]
CefamandoleApprovedBacterial infections[10]
CefazolinApprovedBacterial infections[11]
CefdinirApprovedBacterial infections[12]
CefditorenApprovedBacterial infections[13]
CefepimeApprovedBacterial infections[14]
CefiximeApprovedBacterial infections[15]
CefonicidApprovedBacterial infections[16]
CefoperazoneApprovedBacterial infections[17]
CeforanideApprovedBacterial infections[18]
CefotetanApprovedBacterial infections[14]
CefoxitinApprovedBacterial infections[19]
CefpiramideApprovedBacterial infections[5]
CefpodoximeApprovedBacterial infections[20]
CefprozilApprovedBacterial infections[21]
CefradineApprovedBacterial infections[19]
CeftazidimeApprovedBacterial infections[22]
CeftibutenApprovedBacterial infections[23]
CeftizoximeApprovedBacterial infections[24]
CefuroximeApprovedBacterial infections[25]
CephalexinApprovedBacterial infections[26]
CephaloglycinApprovedBacterial infections[27]
CephapirinApprovedBacterial infections[28]
CloxacillinApprovedBacterial infections[29]
CyclacillinApprovedBacterial infections[5]
DicloxacillinApprovedBacterial infections[30]
ErtapenemApprovedBacterial infections[24]
FlucloxacillinApprovedBacterial infections[30]
HetacillinApprovedBacterial infections[5]
LoracarbefApprovedBacterial infections[20]
MeropenemApprovedBacterial infections[31]
MeticillinApprovedBacterial infections[32]
NafcillinApprovedBacterial infections[33]
OxacillinApprovedBacterial infections[34]
Penicillin GApprovedBacterial infections[15]
Penicillin VApprovedBacterial infections[35]
PiperacillinApprovedBacterial infections[36]
PivampicillinApprovedBacterial infections[5]
PivmecillinamApprovedBacterial infections[37]
TicarcillinApprovedBacterial infections[38]
Target ValidationClick to Find Target Validation Information.    
BinderAmoxicillin[1]
Ampicillin[2]
Azlocillin[4]
Bacampicillin[5]
Carbenicillin[6]
Cefacetrile[7]
Cefaclor[8]
Cefadroxil[9]
Cefamandole[10]
Cefazolin[11]
Cefdinir[12]
Cefditoren[13]
Cefepime[14]
Cefixime[15]
Cefonicid[16]
Cefoperazone[17]
Ceforanide[18]
Cefotetan[14]
Cefoxitin[19]
Cefpiramide[5]
Cefpodoxime[20]
Cefprozil[21]
Cefradine[19]
Ceftazidime[22]
Ceftibuten[23]
Ceftizoxime[24]
Cefuroxime[25]
Cephalexin[26]
Cephaloglycin[27]
Cephapirin[28]
Cloxacillin[29]
Cyclacillin[5]
Dicloxacillin[30]
Ertapenem[24]
Flucloxacillin[30]
Hetacillin[5]
Loracarbef[20]
Meropenem[31]
Meticillin[32]
Nafcillin[33]
Oxacillin[34]
Penicillin G[15]
Penicillin V[35]
Piperacillin[36]
Pivampicillin[5]
Pivmecillinam[37]
Ticarcillin[38]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin. Antimicrob Agents Chemother. 2002 Aug;46(8):2349-57. To Reference
Ref 2Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. To Reference
Ref 3Molecular correlation between in vitro and in vivo activity of beta-lactam and beta-lactamase inhibitor combinations against methicillin-resistant Staphylococcus aureus. J Lab Clin Med. 1995 Feb;125(2):200-11. To Reference
Ref 4Reactivation of peptidoglycan synthesis in ether-permeabilized Escherichia coli after inhibition by beta-lactam antibiotics. Antimicrob Agents Chemother. 1989 Dec;33(12):2101-8. To Reference
Ref 5Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. To Reference
Ref 6Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23. To Reference
Ref 7Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae. Int J Urol. 2008 Sep;15(9):837-42. Epub 2008 Jul 25. To Reference
Ref 8Antibacterial activity of oral cephems against various clinically isolated strains and evaluation of efficacy based on the pharmacokinetics/pharmacodynamics theory. Jpn J Antibiot. 2004 Dec;57(6):465-74. To Reference
Ref 9Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32. To Reference
Ref 10The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1998 Jan;177(1):146-54. To Reference
Ref 11Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9. To Reference
Ref 12Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae. J Antimicrob Chemother. 2007 Jul;60(1):54-60. Epub 2007 May 31. To Reference
Ref 13Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity. Antimicrob Agents Chemother. 2007 Nov;51(11):3902-7. Epub 2007 Aug 27. To Reference
Ref 14In-vitro profile of a new beta-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect. 2007 Jun;13 Suppl 2:17-24. To Reference
Ref 15Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2009 Jun 15. [Epub ahead of print] To Reference
Ref 16Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12. J Antibiot (Tokyo). 1984 May;37(5):572-6. To Reference
Ref 17Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9. To Reference
Ref 18The pharmacokinetics of the interstitial space in humans. BMC Clin Pharmacol. 2003 Jul 30;3:3. To Reference
Ref 19Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains. Antimicrob Agents Chemother. 2008 Nov;52(11):3955-66. Epub 2008 Aug 25. To Reference
Ref 20Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45. Epub 2006 Aug 28. To Reference
Ref 21Microbiology and antimicrobial management of sinusitis. J Laryngol Otol. 2005 Apr;119(4):251-8. To Reference
Ref 22New and emerging treatment of Staphylococcus aureus infections in the hospital setting. Clin Microbiol Infect. 2008 Apr;14 Suppl 3:32-41. To Reference
Ref 23Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins. Curr Opin Infect Dis. 2009 Feb;22(1):87-91. To Reference
Ref 24Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. J Bacteriol. 2005 Mar;187(5):1815-24. To Reference
Ref 25Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI. J Antimicrob Chemother. 2003 Mar;51(3):523-30. To Reference
Ref 26Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21. To Reference
Ref 27Saturation of penicillin-binding protein 1 by beta-lactam antibiotics in growing cells of Bacillus licheniformis. Mol Microbiol. 1995 Apr;16(2):365-72. To Reference
Ref 28The formation of functional penicillin-binding proteins. J Biol Chem. 1975 Aug 25;250(16):6578-85. To Reference
Ref 29Development of a receptor-based microplate assay for the detection of beta-lactam antibiotics in different food matrices. Anal Chim Acta. 2007 Mar 14;586(1-2):296-303. Epub 2006 Sep 26. To Reference
Ref 30Mechanisms of resistance to beta-lactam antibiotics in Staphylococcus aureus. Scand J Infect Dis Suppl. 1984;42:64-71. To Reference
Ref 31Comparative antipneumococcal activities of sulopenem and other drugs. Antimicrob Agents Chemother. 2009 Jun;53(6):2239-47. Epub 2009 Mar 23. To Reference
Ref 32A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus. Microbiology. 2006 Sep;152(Pt 9):2549-58. To Reference
Ref 33Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. J Infect Dis. 1990 Sep;162(3):705-10. To Reference
Ref 34Novel anion liposome-encapsulated antisense oligonucleotide restores susceptibility of methicillin-resistant Staphylococcus aureus and rescues mice from lethal sepsis by targeting mecA. Antimicrob Agents Chemother. 2009 Jul;53(7):2871-8. Epub 2009 May 11. To Reference
Ref 35Localization of penicillin-binding proteins to the splitting system of Staphylococcus aureus septa by using a mercury-penicillin V derivative. J Bacteriol. 1995 Jul;177(13):3631-40. To Reference
Ref 36In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci. J Infect Dis. 2004 Dec 15;190(12):2162-6. Epub 2004 Nov 16. To Reference
Ref 37Association between antimicrobial consumption and resistance in Escherichia coli. Antimicrob Agents Chemother. 2009 Mar;53(3):912-7. Epub 2008 Dec 22. To Reference
Ref 38Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7. To Reference



 

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