Therapeutic Targets Database
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TTD Target ID: TTDS00213

Target Information
NameDNA    
Type of targetSuccessful target    
DiseaseBacterial infections    [1]
Cancer, unspecific    [2][3]
Human immunodeficiency virus [HIV] disease    [4]
Tumors    [5]
Drug(s)AdenineApprovedDietary shortage[6][7]
AltretamineApprovedOvarian cancer[8]
BleomycinApprovedHodgkin lymphoma[9]
BusulfanApprovedMyeloproliferative disease[10]
CarboplatinApprovedOvarian carcinoma[11]
CarmustineApprovedBrain cancer[12][13]
ChlorambucilApprovedChronic lymphatic leukemia[14]
CisplatinApprovedCancers[15]
ClofarabineApprovedAcute lymphoblastic leukemia[16]
ClofazimineApprovedCrohn's disease[17]
CyclophosphamideApprovedCancers[18]
DacarbazineApprovedMalignant melanoma[19]
DactinomycinApprovedCancers[20]
DaunorubicinApprovedAcute myeloid leukemia[20]
Dornase AlfaApprovedCystic fibrosis[21]
FurazolidoneApprovedDiarrhea[22]
Hydroxystilbamidine IsethionateApprovedBlastomycosis[23]
IdoxuridineApprovedHerpes simplex virus infection[24]
IfosfamideApprovedCancers[25]
LomustineApprovedBrain tumours[26]
MechlorethamineApprovedProstate cancer[27]
MelphalanApprovedMultiple myeloma[28]
MercaptopurineApprovedAcute lymphatic leukemia[29]
MethoxsalenApprovedPsoriasis[30]
MetronidazoleApprovedAmebiasis[31]
MitomycinApprovedGastro-intestinal and breast cancers[32]
Mitomycin AApprovedCancers[33]
Mitomycin CApprovedCancers[20]
NelarabineApprovedLeukemia[34]
NitrofurantoinApprovedUrinary tract infection[35]
OxaliplatinApprovedColorectal cancer[36]
OxamniquineApprovedSchistosomiasis[37]
PipobromanApprovedRefractory chronic myeloid leukaemia[38]
PrimaquineApprovedMalaria[39]
ProcarbazineApprovedHodgkin's lymphoma [40]
ProflavineApprovedAntiseptic[41]
StreptozocinApprovedMetastatic islet cell carcinoma[42]
TemozolomideApprovedGrade IV astrocytoma [43]
ThioguanineApprovedAcute myeloid leukemia[44]
Uracil mustardApprovedLymphatic malignancies[45]
BalofloxacinLaunchedGram-positive and -negative bacterial infections[46]
Ciprofloxacin XRLaunchedGram-negative bacterial infections[46]
ElsamitrucinPhase IIMantle Cell Lymphoma, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Advanced Solid Tumors[47]
Abetimus sodiumPhase III teminatedLupus nephritis[48]
GlufosfamideTerminated in Phase IIOvarian cancer[49]
TV-4710Terminated in Phase IISystemic lupus erythematosus[48]
Indol-3-carbinolPreclinicalFungal diseases[50]
Target ValidationClick to Find Target Validation Information.    
Inhibitor2- (3,4-Dihydroxyphenyl)Acetic Acid[51]
Abetimus sodium[48]
Balofloxacin[46]
Beta-D-Glucose[51]
Ciprofloxacin XR[46]
Glufosfamide[49]
Lipid Fragment[51]
Lomustine[26]
Phosphomethylphosphonic Acid Adenosyl Ester[51]
TV-4710[48]
Thiamin Diphosphate[51]
BreakerAltretamine[8]
Bleomycin[9]
Busulfan[10]
Carboplatin[11]
Carmustine[12][13]
Cyclophosphamide[18]
Dacarbazine[19]
Dactinomycin[20]
Dornase Alfa[21]
Duocarmycin[20]
Enediyne antibiotics[20]
Ifosfamide[25]
Mercaptopurine[29]
Metronidazole[31]
Nitracrine[3]
Nitrofurantoin[35]
Streptozocin[42]
Talisomycin[9]
Temozolomide[43]
IntercalatorActinomycin D[52]
Adriamycin[53]
Ametantrone[54]
Chlorambucil[14]
Clofazimine[17]
Daunomycin[55]
Daunorubicin[20]
Elsamitrucin[47]
Ethidium[55]
Ethidium bromide[55]
Mechlorethamine[27]
Melphalan[28]
Nogalamycin[56]
Thioguanine[44]
AdductAnthramycin[57]
Cis-[PtCl (NH3)2[58]
Cisplatin[15]
Ecteinascidins[20]
JM216[59]
Methylene blue[60]
Mitomycin A[33]
Mitomycin C[20]
Naphthyridinomycin[61]
Oxaliplatin[36]
Primaquine[39]
Procarbazine[40]
Tallimustine[62]
Minor groove binderBisbenzimide (Hoechst 33258)[63]
Di-imidazole lexitropsin[64]
Distamycin A[62]
Netropsin[65]
ModulatorUracil mustard[45]
BinderAcriflavine[66]
Adenine[6][7]
Clofarabine[16]
Furazolidone[22]
Hydroxystilbamidine Isethionate[23]
Idoxuridine[24]
Indol-3-carbinol[50]
Methoxsalen[30]
Mitomycin[32]
Nelarabine[34]
Oxamniquine[37]
Pipobroman[38]
Proflavine[41]
MultitargetClofarabine[16]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
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