Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00217

Target Information
Name23S rRNA    
Type of targetSuccessful target    
SynonymsPlastid 23S rRNA    
DiseaseBacterial infections    [1][2]
Malaria    [3]
Drug(s)LinezolidApprovedBacterial infections[4]
MacrolidesApprovedBacterial infections[5]
CethromycinPhase IIIPneumonia,Bacterial infections[6]
EvernimicinDiscontinuedBacterial Infection[7][2]
Target ValidationClick to Find Target Validation Information.    
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. To Reference
Ref 2A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3726-31. Epub 2001 Mar 20. To Reference
Ref 3The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. To Reference
Ref 4Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23. Epub 2009 Apr 6. To Reference
Ref 5Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6. To Reference
Ref 6How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. To Reference
Ref 7Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol. 2003 May 23;329(1):147-57. To Reference
Ref 8Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46. To Reference


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