Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00217

Target Information
Name23S rRNA    
Type of targetSuccessful target    
SynonymsPlastid 23S rRNA    
RrnL    
DiseaseBacterial infections    [1][2]
Malaria    [3]
Drug(s)LinezolidApprovedBacterial infections[4]
MacrolidesApprovedBacterial infections[5]
CethromycinPhase IIIPneumonia,Bacterial infections[6]
EvernimicinDiscontinuedBacterial Infection[7][2]
Target ValidationClick to Find Target Validation Information.    
InhibitorCethromycin[6]
Oxazolidinones[8]
BinderEvernimicin[7][2]
Linezolid[4]
Macrolides[5]
Micrococcin[3]
Spiramycin[3]
Thiostrepton[3]
Zithromax[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. To Reference
Ref 2A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3726-31. Epub 2001 Mar 20. To Reference
Ref 3The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. To Reference
Ref 4Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23. Epub 2009 Apr 6. To Reference
Ref 5Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6. To Reference
Ref 6How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. To Reference
Ref 7Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol. 2003 May 23;329(1):147-57. To Reference
Ref 8Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543