Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00219

Target Information
Name30S ribosomal subunit    
Type of targetSuccessful target    
Synonyms30S ribosome subunit    
DiseaseBacterial infections    [1][2][3]
Drug(s)AmikacinApprovedBacterial infections[4]
ClomocyclineApprovedBacterial infections[5]
DemeclocyclineApprovedBacterial infections[6]
FramycetinApprovedBacterial infections[7]
KanamycinApprovedBacterial infections[8]
LymecyclineApprovedBacterial infections[9]
MeclocyclineApprovedBacterial infections[6]
MethacyclineApprovedBacterial infections[10]
MinocyclineApprovedBacterial infections[11]
NeomycinApprovedAcute hepatic failure and alcoholic cirrhosis of the liver[12]
NetilmicinApprovedBacterial infections[13]
OxytetracyclineApprovedBacterial infections[6]
ParomomycinApprovedAcute and chronic intestinal amebiasis[14][15]
RolitetracyclineApprovedBacterial infections[16]
SpectinomycinApprovedBacterial infections[17]
StreptomycinApprovedBacterial infections[17][18]
TetracyclineApprovedBacterial infections[19]
TigecyclineApprovedBacterial infections[20]
Target ValidationClick to Find Target Validation Information.    
BinderAmikacin[4]
Clomocycline[5]
Demeclocycline[6]
Framycetin[7]
Kanamycin[8]
Lymecycline[9]
Meclocycline[6]
Methacycline[10]
Minocycline[11]
Neomycin[12]
Netilmicin[13]
Oxytetracycline[6]
Paromomycin[14][15]
Rolitetracycline[16]
Spectinomycin[17]
Streptomycin[17][18]
Tetracycline[19]
Tigecycline[20]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Cross-linking of streptomycin to the 50S subunit of Escherichia coli with phenyldiglyoxal. Biochemistry. 1985 Oct 22;24(22):6089-95. To Reference
Ref 2Curr Top Med Chem. 2003;3(9):929-47.Bacterial ribosomal subunit assembly is an antibiotic target. To Reference
Ref 3Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics. Biochem J. 2004 Oct 15;383(Pt 2):201-8. To Reference
Ref 4Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9. To Reference
Ref 5Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5. To Reference
Ref 6Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. To Reference
Ref 7Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26. To Reference
Ref 8SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli. Genes Cells. 2002 Jul;7(7):629-38. To Reference
Ref 9Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. To Reference
Ref 10Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6. To Reference
Ref 11Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. To Reference
Ref 12Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. Epub 2007 Dec 5. To Reference
Ref 13Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6. To Reference
Ref 14Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30. To Reference
Ref 1530S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother. 2002 May;46(5):1546-9. To Reference
Ref 16Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection for the separation of eight tetracyclines in honey samples. J Chromatogr A. 2008 Jun 27;1195(1-2):107-16. Epub 2008 May 10. To Reference
Ref 17Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. To Reference
Ref 18The interaction between streptomycin and ribosomal RNA. Biochimie. 1991 Dec;73(12):1431-8. To Reference
Ref 19The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. To Reference
Ref 20Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543