Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Target ID: TTDS00219

Target Information
Name30S ribosomal subunit    
Type of targetSuccessful target    
Synonyms30S ribosome subunit    
DiseaseBacterial infections    [1][2][3]
Drug(s)AmikacinApprovedBacterial infections[4]
ClomocyclineApprovedBacterial infections[5]
DemeclocyclineApprovedBacterial infections[6]
FramycetinApprovedBacterial infections[7]
KanamycinApprovedBacterial infections[8]
LymecyclineApprovedBacterial infections[9]
MeclocyclineApprovedBacterial infections[6]
MethacyclineApprovedBacterial infections[10]
MinocyclineApprovedBacterial infections[11]
NeomycinApprovedAcute hepatic failure and alcoholic cirrhosis of the liver[12]
NetilmicinApprovedBacterial infections[13]
OxytetracyclineApprovedBacterial infections[6]
ParomomycinApprovedAcute and chronic intestinal amebiasis[14][15]
RolitetracyclineApprovedBacterial infections[16]
SpectinomycinApprovedBacterial infections[17]
StreptomycinApprovedBacterial infections[17][18]
TetracyclineApprovedBacterial infections[19]
TigecyclineApprovedBacterial infections[20]
Target ValidationClick to Find Target Validation Information.    
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Cross-linking of streptomycin to the 50S subunit of Escherichia coli with phenyldiglyoxal. Biochemistry. 1985 Oct 22;24(22):6089-95. To Reference
Ref 2Curr Top Med Chem. 2003;3(9):929-47.Bacterial ribosomal subunit assembly is an antibiotic target. To Reference
Ref 3Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics. Biochem J. 2004 Oct 15;383(Pt 2):201-8. To Reference
Ref 4Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9. To Reference
Ref 5Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5. To Reference
Ref 6Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. To Reference
Ref 7Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26. To Reference
Ref 8SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli. Genes Cells. 2002 Jul;7(7):629-38. To Reference
Ref 9Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. To Reference
Ref 10Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6. To Reference
Ref 11Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. To Reference
Ref 12Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. Epub 2007 Dec 5. To Reference
Ref 13Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6. To Reference
Ref 14Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30. To Reference
Ref 1530S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother. 2002 May;46(5):1546-9. To Reference
Ref 16Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection for the separation of eight tetracyclines in honey samples. J Chromatogr A. 2008 Jun 27;1195(1-2):107-16. Epub 2008 May 10. To Reference
Ref 17Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. To Reference
Ref 18The interaction between streptomycin and ribosomal RNA. Biochimie. 1991 Dec;73(12):1431-8. To Reference
Ref 19The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. To Reference
Ref 20Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110. To Reference


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