Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00309

Target Information
NameHBV polymerase    
Type of targetSuccessful target    
DiseaseHepatitis B    [1]
Drug(s)Adefovir DipivoxilApprovedHepatitis B[2]
EntecavirApprovedHepatitis B infection[2]
LamivudineApprovedHIV infection and chronic hepatitis B[2]
TelbivudineApprovedHepatitis B infection[2]
BioChemical ClassDNA-directed DNA polymerase    
UniProt IDQ67889
SequenceMPLSYQHFRKLLLLDDGTGPLEEELPRLADEGLNRRVAEDLNLGNLNVSIPWTHKVGNFT GLYSSTVPVFNPHWKTPSFPNIHLHQDIIKKCEQFVGPLTVNEKRRLQLIMPARFYPKVT KYLPLDKGIKPYYPEHLVNHYFQTRHYLHTLWKAGILYKRETTHSASFCGSPYSWEQDLQ HGAESIHQQSSGILSRPPVGSSLQSKHRKSRLGLQSQQGHLARRQQGRSWSIRAGFHPTA RRPFGVEPSGSGHTTNFASKSASCLHQSPVRKAAYPSVSTFEKHSSSGHAVELHNLPPNS ARSKSERPVFPCWWLQFRNSKPCSDYCLSLIVNLREDWGPCDDHGEHHIRIPRTPARVRG GVFLVDKNPHNTAESRLVVDFSQFSRGNYRVSWPKFAVPNLPSLTNLLSSNLSWLSLDVS AAFYHIPLHPAAMPHLLVGSSGLSRYVARLSSNSRYFNNQHGTMQNLHDSCSRNLYVSLL LLYQTFGRKLHLYSHPIILGFRKIPMAVGLSPFLLAQFTSAICSVVRRAFPHCLGFSYMD DVVLGAKSVQHRESLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYIIGSWGTLPQDHI VQKIKHCFRKLPVNRPIDWKVWQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSP TYKAFLSKQYMNLYPVARQRPGLCQVFADATPTGWGLA
Related US Patent6,528,252
Target ValidationClick to Find Target Validation Information.    
InhibitorAdefovir Dipivoxil[2]
Entecavir[2]
Lamivudine[2]
Telbivudine[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations. HIV Med. 2009 Apr;10(4):229-35. Epub 2009 Jan 28. To Reference
Ref 2Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92. To Reference



 

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