Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00442

Target Information
NameGranulocyte-macrophage colony-stimulating factor receptor alpha chain    
Type of targetSuccessful target    
SynonymsCD116 antigen    
CDw116    
GM-CSF-R-alpha    
GM-CSFR    
GMR    
DiseaseLeukemia, unspecified    [1]
Solid tumor    [1]
Drug(s)SargramostimApprovedBone marrow transplantation[2][3]
MavrilimumabPhase IIRheumatoid arthritis[4]
BioChemical ClassTransmembrane protein    
PathwayCytokine-cytokine receptor interaction
Hematopoietic cell lineage
Jak-STAT signaling pathway
Pathways in cancer
UniProt IDP15509
PDB Structure3CXE.    
FunctionLow affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.    
SequenceMLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKC FLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTA AQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHL DNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQP RTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAAD VRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVP QIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT
AntibodyMavrilimumab[4]
BinderSargramostim[2][3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells. Blood. 1997 Jul 1;90(1):252-9. To Reference
Ref 2Stem cell transplantation and hematopoietic growth factors. Curr Hematol Rep. 2002 Nov;1(2):103-9. To Reference
Ref 3Economic evaluation of filgrastim, sargramostim, and sequential sargramostim and filgrastim after myelosuppressive chemotherapy. Bone Marrow Transplant. 2002 Jan;29(2):159-64. To Reference
Ref 42011 Pipeline of MedImmune. To Reference



 

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