Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Target ID: TTDS00467

Target Information
NameAntithrombin-III    
Type of targetSuccessful target    
SynonymsAT3    
ATIII    
SERPINC1    
DiseaseThrombosis    [1]
Drug(s)HeparinApprovedAcute coronary syndrome[2]
SulodexideApprovedCentral or sensorineural tinnitus[1][3]
TinzaparinApprovedDeep vein thrombosis and pulmonary embolism[4][5]
UniProt IDP01008
PDB Structure1NQ9; 1OYH; 1R1L; 1SR5.    
FunctionMost important serine protease inhibitor in plasma that regulates the blood coagulation cascade. At-iii inhibits thrombin as well as factors ixa, xa and xia. Its inhibitory activity is greatly enhanced in the presence of heparin.    
SequenceMYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
InhibitorAlpha-D-Mannose[6]
Heparin Pentasaccharide[6]
N-Formylmethionine[6]
ActivatorSulodexide[1][3]
CofactorHeparin[2]
Tinzaparin[4][5]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20. To Reference
Ref 2Antithrombin-heparin covalent complex: a possible alternative to heparin for arterial thrombosis prevention. Circulation. 2002 Jul 9;106(2):261-5. To Reference
Ref 3Management of tinnitus: oral treatment with melatonin and sulodexide. J Biol Regul Homeost Agents. 2009 Apr-Jun;23(2):103-10. To Reference
Ref 4Thrombin generation assays are superior to traditional tests in assessing anticoagulation reversal in vitro. Thromb Haemost. 2008 Aug;100(2):350-5. To Reference
Ref 5Low-molecular-weight heparin in patients with renal insufficiency. Swiss Med Wkly. 2009 Aug 8;139(31-32):438-52. To Reference
Ref 6Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543