|Target Name||Smoothened |
|Type of Target||Clinical trial target |
|Drug Potency against Target||CYCLOPAMINE||IC50 = 1200 nM|||
|1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine||IC50 = 2246 nM|||
|Ref 1||Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. Epub 2008 Dec 3.Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. To Reference|
|Ref 2||J Med Chem. 2009 Jul 9;52(13):3954-68.1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. To Reference|
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Deputy Director of Center
for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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