Therapeutic Targets Database
BIDD Pharmainformatics Databases


Target Validation Information
Target NameSmoothened    
Type of TargetClinical trial target    
Drug Potency against TargetCYCLOPAMINEIC50 = 1200 nM[1]
1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazineIC50 = 2246 nM[2]
Ref 1Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. Epub 2008 Dec 3.Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. To Reference
Ref 2J Med Chem. 2009 Jul 9;52(13):3954-68.1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. To Reference


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