Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDR00007
Target NameMultidrug resistance protein 1    
Type of TargetResearch target    
Drug Potency against Target[1,1';2',1'']-terphenyl-4,3'',5''-triolIC50 = 12000 nM[1]
6-(3,5-dimethoxy-phenyl)-naphthalen-2-olIC50 = 16000 nM[1]
4,3'',5''-trimethoxy-[1,1';2',1'']-terphenylIC50 = 16000 nM[1]
ELACRIDARIC50 = 2000 nM[2]
XR-9504IC50 = 260 nM[3]
XR-9456IC50 = 300 nM[3]
XR-9577IC50 = 320 nM[3]
XR-9544IC50 = 50 nM[3]
TRISMETHOXYRESVERATROLIC50 = 8000 nM[1]
Ref 1J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. To Reference
Ref 2J Med Chem. 2008 Dec 11;51(23):7602-13.2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. To Reference
Ref 3Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. To Reference



 

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