Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDR00620
Target NameVoltage-dependent L-type calcium channel alpha-1D subunit    
Type of TargetResearch target    
Drug Potency against TargetNILVADIPINEIC50 = 1.04 nM[1]
N,N'-Di-acenaphthen-5-yl-guanidineIC50 = 1130 nM[2]
PD-32577IC50 = 2000 nM[3]
SIPATRIGINEIC50 = 3860 nM[2]
CGS-27830IC50 = 592 nM[4]
CV-4093IC50 = 8.68 nM[1]
BELFOSDILKi = 23 nM[5]
(+)-NIGULDIPINEKi = 4.6 nM[6]
SNAP-5089Ki = 540 nM[6]
(-)-NIGULDIPINEKi = 59.7 nM[7]
Ref 1J Med Chem. 1989 Oct;32(10):2399-406.Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. To Reference
Ref 2Bioorg. Med. Chem. Lett. 5(19):2259-2262 (1995) To Reference
Ref 3Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. To Reference
Ref 4Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993) To Reference
Ref 5Bioorg. Med. Chem. Lett. 3(12):2817-2820 (1993) To Reference
Ref 6J Med Chem. 1995 May 12;38(10):1579-81.Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. To Reference
Ref 7J Med Chem. 1996 Jul 19;39(15):2980-9.Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. To Reference



 

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