Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDR00957
Target NameAdenosylhomocysteinase    
Type of TargetResearch target    
Drug Potency against Target5-methylenearisteromycinIC50 = 15700 nM[1]
ERITADENINEIC50 = 30 nM[2]
NORARISTEROMYCINIC50 = 3100 nM[3]
FLUORO-NEPLANOCIN AIC50 = 480 nM[4]
ARISTEROMYCINIC50 = 4850 nM[1]
5'-deoxy-5'-ureidoadenosineIC50 = 7530 nM[5]
Ref 1Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. Epub 2008 Jan 30.Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. To Reference
Ref 2Bioorg Med Chem. 2009 Sep 15;17(18):6707-14. Epub 2009 Jul 28.A new structural class of S-adenosylhomocysteine hydrolase inhibitors. To Reference
Ref 3Bioorg Med Chem Lett. 2008 Apr 15;18(8):2615-8. Epub 2008 Mar 14.Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase. To Reference
Ref 4Bioorg Med Chem Lett. 2004 Nov 15;14(22):5641-4.Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase. To Reference
Ref 5Bioorg Med Chem Lett. 2007 Aug 15;17(16):4456-9. Epub 2007 Jun 8.Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase. To Reference



 

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Professor in Department of Pharmacy
National University of Singapore, Singapore


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