Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDR01266
Target NameNeutrophil collagenase    
Type of TargetSuccessful target    
Drug Potency against TargetMarimastatIC50 = 2 nM[1]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamideIC50 = 1000 nM[2]
2-(biphenyl-4-ylsulfonamido)pentanedioic acidIC50 = 1024 nM[3]
3-(4-Methoxy-benzenesulfonyl)-propane-1-thiolIC50 = 1100 nM[4]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic AcidIC50 = 290 nM[2]
BB-1101IC50 = 3 nM[5]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiolIC50 = 4 nM[4]
CGS-27023AIC50 = 4.4 nM[6]
Ro-37-9790IC50 = 4.9 nM[7]
3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiolIC50 = 585 nM[4]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamideIC50 = 620 nM[2]
4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acidIC50 = 670 nM[3]
Ro-32-3555IC50 = 7 nM[7]
3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiolIC50 = 8 nM[4]
ILOMASTATKi < 1 nM[8]
SC-44463Ki = 0.7 nM[9]
IK-682Ki = 257 nM[10]
CIPEMASTATKi = 4 nM[11]
Ref 1Curr Pharm Des. 2005;11(3):295-322.Recent developments in the design of specific Matrix Metalloproteinase inhibitors aided by structural and computational studies. To Reference
Ref 2J Med Chem. 2009 Oct 22;52(20):6347-61.Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors. To Reference
Ref 3Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. Epub 2008 Mar 8.Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. To Reference
Ref 4Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60.Synthesis and identification of conformationally constrained selective MMP inhibitors. To Reference
Ref 5J Med Chem. 1999 Nov 18;42(23):4890-908.New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. To Reference
Ref 6J Med Chem. 1999 Nov 4;42(22):4547-62.Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. To Reference
Ref 7Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997) To Reference
Ref 8Bioorg. Med. Chem. Lett. 5(4):349-352 (1995) To Reference
Ref 9J Med Chem. 2001 Oct 11;44(21):3347-50.Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. To Reference
Ref 10J Med Chem. 2002 Nov 7;45(23):4954-7.Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. To Reference
Ref 11J Med Chem. 2000 Feb 10;43(3):305-41.Protease inhibitors: current status and future prospects. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543