Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDS00295
Target NameFatty acid synthase    
Type of TargetSuccessful target    
Drug Potency against TargetCeruleninIC50 = 1 mol[1]
FISETINIC50 = 2000 nM[2]
4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-oneIC50 = 3000 nM[3]
EPICATECHIN GALLATEIC50 = 400 nM[2]
EPIGALOCATECHIN GALLATEIC50 = 400 nM[2]
4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-oneIC50 = 550 nM[3]
GALLOCATECHIN GALLATEIC50 = 600 nM[2]
BIOCHANINIC50 = 8000 nM[2]
MORINIC50 = 8000 nM[2]
(-)-CATECHINGALLATEKi = 2800 nM[2]
2-Hexadecynoic acidKi = 4800 nM[4]
Ref 1J Biochem. 1989 May;105(5):751-5.Binding site of cerulenin in fatty acid synthetase. To Reference
Ref 2J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. To Reference
Ref 3Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. To Reference
Ref 4Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. To Reference



 

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