Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDS00303
Target NameNicotinic acetylcholine receptor    
Type of TargetSuccessful target    
Drug Potency against TargetNicotineEC50 = 4600 nM[1]
NicotineKi = 19.4 nM[2]
DianiclineKi = 42900 nM[3]
PROTOSTEMODIOLIC50 = 10000 nM[4]
Ref 1Curr Top Med Chem. 2004;4(3):299-334.Design of ligands for the nicotinic acetylcholine receptors: the quest for selectivity. To Reference
Ref 2Curr Top Med Chem. 2004;4(3):361-8.Receptor binding thermodynamics at the neuronal nicotinic receptor. To Reference
Ref 3Mini Rev Med Chem. 2008 Mar;8(3):290-306.Low molecular weight inhibitors of the protease anthrax lethal factor. To Reference
Ref 4J Nat Prod. 2008 Jan;71(1):112-6. Epub 2007 Dec 29.Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. To Reference



 

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National University of Singapore, Singapore


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