Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

Target Validation Information
TTD IDTTDS00338
Target NamePeroxisome proliferator activated receptor gamma    
Type of TargetSuccessful target    
Drug Potency against TargetRosiglitazoneEC50 = 40 nM[1]
PioglitazoneEC50 = 580 nM[1]
NetoglitazoneEC50 = 100 nM[2]
Rosiglitazone XREC50 = 200 nM[3]
Rosiglitazone & metforminEC50 = 200 nM[3]
Rosiglitazone & simvastatinEC50 = 200 nM[3]
Rosiglitazone & simvastatinIC50 = 23 nM[4]
TESAGLITAZARKi = 200 nM[5]
Ref 1Curr Top Med Chem. 2005;5(3):265-82.Nuclear receptors as potential targets for modulating reverse cholesterol transport. To Reference
Ref 2Expert Opin Investig Drugs. 2003 Apr;12(4):623-33.Treatment of non-insulin-dependent diabetes mellitus. To Reference
Ref 3J Biol Chem. 1998 Dec 4;273(49):32679-84.A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. To Reference
Ref 4Curr Opin Pharmacol. 2005 Aug;5(4):366-73.Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. To Reference
Ref 5J Med Chem. 2004 Aug 12;47(17):4118-27.Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes. To Reference



 

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Professor in Department of Pharmacy
National University of Singapore, Singapore


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