Therapeutic Targets Database
BIDD Pharmainformatics Databases


Target Validation Information
Target NameFungal Cytochrome P450 51    
Type of TargetSuccessful target    
Drug Potency against TargetKetoconazoleIC50 = 9 nM[1]
KetoconazoleKi = 2800 nM[2]
TioconazoleKi = 400 nM[1]
ANALOGUE AIC50 = 300 nM[3]
CP-320626IC50 = 4000 nM[3]
Ref 1Curr Drug Discov Technol. 2006 Mar;3(1):1-48.Development and validation of an in silico P450 profiler based on pharmacophore models. To Reference
Ref 2Science. 2008 Jul 11;321(5886):263-6.Drug target identification using side-effect similarity. To Reference
Ref 3Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28.Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. To Reference


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