Therapeutic Targets Database
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Target Validation Information
TTD IDTTDS00373
Target NameTyrosine oxidase    
Type of TargetSuccessful target    
Drug Potency against Target1-(But-2-enylidene)thiosemicarbazideIC50 = 1000 nM[1]
SRI-224IC50 = 110 nM[2]
N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamideIC50 = 11000 nM[3]
7,8,4'-trihydroxyisoflavoneIC50 = 11210 nM[4]
1-(4-Methylpent-3-en-2-ylidene)thiosemicarbazideIC50 = 11500 nM[1]
KOJIC ACIDIC50 = 12000 nM[5]
OXYRESVERATROLIC50 = 12700 nM[6]
SODIUM ZINC DIHYDROLIPOYLHISTIDINATEIC50 = 1300 nM[7]
ASKENDOSIDE BIC50 = 13950 nM[8]
1-(1-(thiophen-2-yl)ethylidene)thiosemicarbazideIC50 = 140 nM[9]
2-hydroxyphenethyl 3,4,5-trihydroxybenzoateIC50 = 14500 nM[10]
2-(butylthiomethyl)-5-hydroxy-4H-pyran-4-oneIC50 = 1480 nM[11]
1-(1,4-diacetylphenyl)dithiosemicarbazideIC50 = 150 nM[9]
N-butylresorcinolIC50 = 150 nM[12]
1-(3-Oxocyclohexylidene)thiosemicarbazideIC50 = 15100 nM[1]
3-hydroxyphenethyl 3,4,5-trihydroxybenzoateIC50 = 15210 nM[10]
3hydroxy-1-methyl-1-phenylureaIC50 = 16000 nM[13]
5-(6-hydroxynaphthalen-2-yl)benzene-1,3-diolIC50 = 16520 nM[14]
1-(1-(4-fluorophenyl)ethylidene)thiosemicarbazideIC50 = 170 nM[9]
1-CyclopentylidenethiosemicarbazideIC50 = 170 nM[1]
N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamideIC50 = 17000 nM[3]
1'-(4-Methyl-benzyl)-[1,4']bipiperidinylIC50 = 1720 nM[15]
PHENYLTHIOUREAIC50 = 1800 nM[13]
2-(hexylthiomethyl)-5-hydroxy-4H-pyran-4-oneIC50 = 190 nM[11]
5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-oneIC50 = 1930 nM[11]
1-(3-phenoxypropyl)-4-(piperidin-1-yl)piperidineIC50 = 19520 nM[15]
1-PropylidenethiosemicarbazideIC50 = 200 nM[1]
3-(2,4-dihydroxyphenyl)-propionic acid ethylesterIC50 = 220 nM[16]
1-EthylidenethiosemicarbazideIC50 = 230 nM[1]
1-hydroxy-3-(4-nitrophenyl)ureaIC50 = 2600 nM[13]
2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-oneIC50 = 2600 nM[11]
ETHISTERONEIC50 = 2610 nM[17]
2-(heptylthiomethyl)-5-hydroxy-4H-pyran-4-oneIC50 = 2650 nM[11]
1-(1-p-tolylethylidene)thiosemicarbazideIC50 = 270 nM[9]
1-(3-Phenylallylidene)thiosemicarbazideIC50 = 2700 nM[1]
1-(4-bromophenyl)-3-hydroxyureaIC50 = 2700 nM[13]
1-(Butan-2-ylidene)thiosemicarbazideIC50 = 280 nM[1]
1-hydroxy-3-phenylureaIC50 = 290 nM[13]
5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriolIC50 = 2950 nM[18]
3,4-dihydroxybenzaldehyde-O-ethyloximeIC50 = 300 nM[2]
2,2',4,4'-tetrahydroxy-6'-methoxychalconeIC50 = 3100 nM[19]
4-(6-hydroxynaphthalen-2-yl)benzene-1,3-diolIC50 = 34 nM[14]
1-(1-phenylethylidene)thiosemicarbazideIC50 = 340 nM[9]
4,4'-(ethane-1,2-diyl)dibenzene-1,3-diolIC50 = 370 nM[20]
TROPOLONEIC50 = 400 nM[2]
1-hydroxy-3-(4-(trifluoromethyl)phenyl)ureaIC50 = 4300 nM[13]
7-(3,5-dihydroxyphenyl)naphthalene-1,3-diolIC50 = 490 nM[14]
4-hydroxyphenethyl 3,4,5-trihydroxybenzoateIC50 = 4930 nM[10]
2,2',4,4'-tetrahydroxychalconeIC50 = 5000 nM[19]
1-(1-(4-bromophenyl)ethylidene)thiosemicarbazideIC50 = 520 nM[9]
7,3',4'-trihydroxyisoflavoneIC50 = 5230 nM[4]
1-(3-Methylbutylidene)thiosemicarbazideIC50 = 620 nM[1]
1-(4-(benzyloxy)phenyl)-3-hydroxyureaIC50 = 6300 nM[13]
6-(3-hydroxyphenyl)naphthalen-2-olIC50 = 6400 nM[14]
3-(2,4-dihydroxyphenyl)-propionic acid octylesterIC50 = 700 nM[16]
1-(1-(pyridin-3-yl)ethylidene)thiosemicarbazideIC50 = 820 nM[9]
1-(2,5-Dimethyl-1H-pyrrol-1-yl)thioureaIC50 = 850 nM[1]
1-(Propan-2-ylidene)thiosemicarbazideIC50 = 86 nM[1]
2-(cyclohexylthiomethyl)-5-hydroxy-4H-pyran-4-oneIC50 = 87 nM[11]
1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazideIC50 = 880 nM[9]
4-adamantyl resorcinolIC50 = 900 nM[12]
1-CyclohexylidenethiosemicarbazideIC50 = 950 nM[1]
5-hydroxy-2-(pentylthiomethyl)-4H-pyran-4-oneIC50 = 97 nM[11]
4-hexyl resorcinolIC50 = 980 nM[21]
kazinol CKi = 11200 nM[22]
4'-(4-Nitrobenzensulfonamide)-4-hydroxychalconeKi = 11400 nM[23]
4'-(p-Toluenesulfonamide)-4-hydroxychalconeKi = 12600 nM[23]
N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamideKi = 1300 nM[3]
5-phenyl-1,3,4-thiadiazole-2(3H)-thioneKi = 1310 nM[24]
4'-(Benzensulfonamide)-4-hydroxychalconeKi = 13300 nM[23]
5-(pyridin-4-yl)-1,3,4-oxadiazole-2(3H)-thioneKi = 14200 nM[24]
4'-(4-Fluorobenzensulfonamide)-4-hydroxychalconeKi = 14900 nM[23]
KAZINOL SKi = 15600 nM[22]
4'-(4-Aminobenzensulfonamide)-4-hydroxychalconeKi = 16700 nM[23]
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thioneKi = 1770 nM[24]
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thioneKi = 18500 nM[24]
2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-oneKi = 20 nM[25]
5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thioneKi = 2470 nM[24]
broussonin CKi = 290 nM[22]
2,2'-bi(1,3,4-thiadiazole)-5,5'(4H,4'H)-dithioneKi = 2900 nM[24]
4',4-DihydroxychalconeKi = 2900 nM[23]
2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-oneKi = 3300 nM[25]
5-benzyl-1,3,4-oxadiazole-2(3H)-thioneKi = 3670 nM[24]
4'-Amino-4-hydroxychalconeKi = 3900 nM[23]
5,5'-methylenebis(1,3,4-oxadiazole-2(3H)-thione)Ki = 4420 nM[24]
5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione)Ki = 490 nM[24]
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thioneKi = 4940 nM[24]
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thioneKi = 5200 nM[24]
2,4,3',5'-tetrahydroxybibenzylKi = 5600 nM[6]
HINOKITIOLKi = 60 nM[25]
5-phenyl-1,3,4-oxadiazole-2(3H)-thioneKi = 6470 nM[24]
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thioneKi = 6760 nM[24]
kazinol FKi = 770 nM[22]
Ref 1Eur J Med Chem. 2009 Apr;44(4):1773-8. Epub 2008 Apr 27.A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. To Reference
Ref 2Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60. Epub 2009 Sep 10.Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. To Reference
Ref 3Bioorg Med Chem Lett. 2006 May 15;16(10):2682-4. Epub 2006 Mar 2.N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. To Reference
Ref 4Bioorg Med Chem Lett. 2010 Feb 1;20(3):1162-4. Epub 2009 Dec 6.Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors. To Reference
Ref 5Bioorg Med Chem Lett. 2010 Dec 15;20(24):7393-6. Epub 2010 Oct 14.A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol. To Reference
Ref 6Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3. Epub 2006 Aug 17.Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. To Reference
Ref 7Bioorg Med Chem. 2007 Mar 1;15(5):1967-75. Epub 2006 Dec 31.Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products. To Reference
Ref 8Bioorg Med Chem Lett. 2006 Jan 15;16(2):324-30. Epub 2005 Nov 3.New tyrosinase inhibitors selected by atomic linear indices-based classification models. To Reference
Ref 9Bioorg Med Chem. 2008 Feb 1;16(3):1096-102.1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. To Reference
Ref 10Bioorg Med Chem Lett. 2007 Oct 1;17(19):5462-4. Epub 2007 Jul 25.Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors. To Reference
Ref 11Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. Epub 2010 Sep 21.Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. To Reference
Ref 12Bioorg Med Chem Lett. 2009 Mar 1;19(5):1532-3. Epub 2009 Jan 1.Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety. To Reference
Ref 13Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. To Reference
Ref 14Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. Epub 2006 Oct 12.Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. To Reference
Ref 15Eur J Med Chem. 2007 Nov-Dec;42(11-12):1370-81. Epub 2007 Feb 23.Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays. To Reference
Ref 16J Med Chem. 2007 May 31;50(11):2676-81. Epub 2007 Apr 21.Enhanced substituted resorcinol hydrophobicity augments tyrosinase inhibition potency. To Reference
Ref 17Bioorg Med Chem. 2007 Feb 1;15(3):1483-503. Epub 2006 Nov 2.TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-based linear indices. To Reference
Ref 18Bioorg Med Chem Lett. 2010 Aug 15;20(16):4882-4. Epub 2010 Jun 19.A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol. To Reference
Ref 19Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. Epub 2007 Jan 17.Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors. To Reference
Ref 20Bioorg Med Chem Lett. 2008 Oct 1;18(19):5252-4. Epub 2008 Aug 22.Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton. To Reference
Ref 21Bioorg Med Chem Lett. 2009 Jan 1;19(1):36-9. Epub 2008 Nov 13.PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase. To Reference
Ref 22Bioorg Med Chem. 2009 Jan 1;17(1):35-41. Epub 2008 Nov 18.Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. To Reference
Ref 23Eur J Med Chem. 2010 May;45(5):2010-7. Epub 2010 Jan 28.Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. To Reference
Ref 24Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. To Reference
Ref 25Bioorg Med Chem. 2010 Nov 15;18(22):8112-8. Epub 2010 Oct 12.Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. To Reference



 

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Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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