Therapeutic Targets Database
BIDD Pharmainformatics Databases


Target Validation Information
Target NameMelatonin receptor type 1A    
Type of TargetSuccessful target    
Drug Potency against TargetRamelteonKi = 0.014 nM[1]
RamelteonKi = 14 nM[2]
AgomelatineIC50 = 0.062 nM[1]
LY-156735IC50 = 0.081 nM[1]
N-(2-(5-methoxybenzofuran-3-yl)ethyl)acetamideIC50 = 0.6 nM[3]
5-methoxycarbonylamino-N-acetyltryptamineIC50 = 100 nM[3]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-oneKi < 1000 nM[4]
beta,beta-dimethylmelatoninKi = 1.12 nM[6]
UCM-454Ki = 1.4 nM[7]
beta-methylmelatoninKi = 1.67 nM[6]
N-(3-(2,5-dimethoxyphenyl)propyl)acetamideKi = 1280 nM[8]
N-[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-acetamideKi = 1640 nM[9]
N-(3-(2-ethoxy-5-methoxyphenyl)propyl)acetamideKi = 183 nM[8]
N-(2,3-Dihydro-1H-phenalen-2-yl)-acetamideKi = 195 nM[9]
N-(3-(3-methoxyphenyl)propyl)acetamideKi = 23.3 nM[8]
N-(3-(3-methoxyphenyl)-3-phenylallyl)acetamideKi = 230 nM[7]
N-(3-(4-hydroxy-3-methoxyphenyl)propyl)acetamideKi = 257 nM[8]
N-(3-(2-hydroxy-5-methoxyphenyl)propyl)acetamideKi = 379 nM[8]
N-(3-(5-methoxy-2-propoxyphenyl)propyl)acetamideKi = 400 nM[8]
N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)-acetamideKi = 5350 nM[10]
N-(3-(3-methoxyphenyl)propyl)propionamideKi = 85.4 nM[8]
Ref 1Curr Top Med Chem. 2008;8(11):954-68.Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. To Reference
Ref 2Trends Pharmacol Sci. 2001 Aug;22(8):409-14.Therapeutic opportunities from muscarinic receptor research. To Reference
Ref 3Bioorg Med Chem. 2008 May 1;16(9):4954-62. Epub 2008 Mar 17.Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. To Reference
Ref 4J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. To Reference
Ref 5J Med Chem. 2002 Apr 25;45(9):1853-9.Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3). To Reference
Ref 6J Med Chem. 2006 Jun 15;49(12):3509-19.Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines. To Reference
Ref 7J Med Chem. 2009 Feb 12;52(3):826-33.2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. To Reference
Ref 8Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. Epub 2010 Feb 25.Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. To Reference
Ref 9J Med Chem. 1996 Aug 2;39(16):3089-95.Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. To Reference
Ref 10Bioorg. Med. Chem. Lett. 4(13):1559-1564 (1994) To Reference


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