|Target Name||Voltage-gated sodium channel subunit alpha Nav1.7 |
|Type of Target||Successful target |
|Drug Potency against Target||4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole||IC50 = 1940 nM|||
|4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole||IC50 = 2160 nM|||
|4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazole||IC50 = 5310 nM|||
|V-102862||Ki = 360 nM|||
|Ref 1||Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. To Reference|
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Professor in Department of Pharmacy
National University of Singapore, Singapore
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