Therapeutic Targets Database
BIDD Pharmainformatics Databases


Target Validation Information
Target NameVoltage-gated sodium channel subunit alpha Nav1.7    
Type of TargetSuccessful target    
Drug Potency against Target4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazoleIC50 = 1940 nM[1]
4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazoleIC50 = 2160 nM[1]
4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazoleIC50 = 5310 nM[1]
V-102862Ki = 360 nM[1]
Ref 1Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. Epub 2010 Jul 21.Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. To Reference


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